PEPTIDE-MODIFIED PAMAM-BASED BONE-TARGETING RNA DELIVERY SYSTEM

Peptide-modified PAMAM-based bone-targeting RNA delivery system

Abstract Background Osteoporosis, among other bone diseases, has become a prevalent cause of decreased quality of life in older and postmenopausal women.Traditional anti-osteoporotic therapies, though widely prescribed, are limited by a lack of cell- or tissue-specific targeting ability and effectiveness without side effects.Gene therapy Ball - Ump

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System failure probability analysis of cohesive slope considering the spatial variability of undrained shear strength

A system failure probability analysis method of cohesive slope considering the spatial variability of undrained shear strength is proposed.In this method, Other Panels the local averaging parameter of the random field of undrained shear strength on slip surface is introduced as an equivalent parameter.The statistical characters of the equivalent pa

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Morphology and ultrastructure of retrovirus particles

Retrovirus morphogenesis entails assembly of Gag proteins and the viral genome on the host plasma membrane, acquisition of the viral membrane and envelope proteins through budding, and formation of the core through the Chargers maturation process.Although in both immature and mature retroviruses, Gag and capsid proteins are organized as paracrystal

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